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Composition of Pueraria Mirifica

Our researcher has started research on Pueraria Mirifica since 1991 and then later on Butea.
The compounds that make Pueraria Mirifica different from any other phyto-estrogen containing plants in the Family Leguminous are Miroestrol and Deoxymiroestrol, which possess highest estrogenic activity among the known phyto-estrogens due to structural similarity to estradiol, Miroestrol was actually the first compound isolated from this plant by a group of German chemists in 1940, but the plant had been mistakenly reported then as Butea Superba. It was later on classified as a new plant called Pueraria Mirifica Airy Shaw et Suvatabhandu.

The isolation and identification of deoxymiroestrol from the root of Pueraria Mirifica has just been reported in the February 2000 issue of the Journal of Natural Products, The authors proposed that since deoxymiroestrol is easily oxidized to miroestrol, deoxymiroestrol, not the previously reported miroestrol, is more likely to be the actual chemical constituent of Pueraria Mirifica.

However, it is very likely that the two phyto-estrogens coexist in the root of this plant. As shown below, the chemical structures of two compounds are very similar to that of estradiol, the main human estrogen.

In addition to miroestrol and deoxymiroestrol, Pueraria Mirifica also contains other chemicals that belong to isoflavones and Coumestan groups of phyto-estrogens, e.g., Genistein, Daidzein, Daidzin, Genistin, and Coumestrol that are usually found in soybeans (Table 1). However, the estrogenic activity of Miroestrol and Deoxymiroestrol is much more potent than that of soy isoflavones.

Table 1: Chromene, Isoflavonoid and Coumestan derivatives in Pueraria Mirifica
Chromene
Isoflavones
Isoflavones glycosides
Coumestan
Miroestrol
Daidzein
Daidzin
Coumestrol
Deoxymiroestrol
Genistein
Genistin
Mirificoumestan
 
Kwakhurin
Mirificin
Mirificoumestan glycol
 
Kwakhurin hydrate
Puerarin
Mirificoumestan hydrate
   
Puerarin-6" monoacetate
 

Estradiol
Deoxymiroestrol
Mirificoumestan

What is benefit effects of Chemical composition from Pueraria Mirifica?
While Soya and Alfalfa contains low amount and low estrogenic of the phyto-estrogens, many researches pointed out the benefit effects of those chemicals, especially to act as a Potent Anti-Breast Cancer, Anti-Prostate Cancer, Anti-Colon Cancer, Anti-Cardio-Vascular disease via the reduction of blood cholesterol and also Anti-Menopausal Syndrome. The phyto-estrogens in the Pueraria Mirifica (White Kwao Krua) is more concentrated and higher efficacy. By this distinguish property, biotechnology application has shown up for this herb.

Source:Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health, Thailand; July 2000

 
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